We used NetPyNE to build and simulate large-scale and biologically realistic models of rodent motor (M1), rodent somatosensory (S1), and macaque auditory (A1) thalamocortical circuits. Each model simulates a cortical column and corresponding thalamic circuits and contains in the order of ~15k detailed neurons ~30M synapses. The model neuronal densities, classes, morphology, biophysics, and connectivity were derived from experimental data. The rodent M1 and S1 models are being used to study neural coding and learning in corticothalamic circuits of the sensorimotor pathway. The macaque A1 model is being used to explore oscillatory mechanisms in the context of speech processing and related disorders. The models may help better understand a variety of diseases, including schizophrenia, Alzherimer’s disease, epilepsy, and motor disorders. See publications [7-10].